Logo - Adolf Würth Präventionspraxis Zitat - Praxis für Diagnostik - Prof. Dr. med. habil. Christoph A. Karle - Künzelsau Logo - Praxis für Diagnostik - Prof. Dr. med. habil. Christoph A. Karle - Künzelsau



| Wissenschaftliche Publikationen

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[The Wearable Cardioverter-Defibrillator (WCD)].
Helms TM, Müller A, Schwab JO, Bänsch D, Karle C, Klingenheben T, Zugck C, Perings C. Herzschrittmacherther Elektrophysiol. 2015 Jun;26(2):129-33. doi: 10.1007/s00399-015-0365-7. Epub 2015 May 5. German.

Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure.
Packer M, McMurray JJ, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile M, Andersen K, Arango JL, Arnold JM, Bělohlávek J, Böhm M, Boytsov S, Burgess LJ, Cabrera W, Calvo C, Chen CH, Dukat A, Duarte YC, Erglis A, Fu M, Gomez E, Gonzàlez-Medina A, Hagège AA, Huang J, Katova T, Kiatchoosakun S, Kim KS, Kozan Ö, Llamas EB, Martinez F, Merkely B, Mendoza I, Mosterd A, Negrusz-Kawecka M, Peuhkurinen K, Ramires FJ, Refsgaard J, Rosenthal A, Senni M, Sibulo AS Jr, Silva-Cardoso J, Squire IB, Starling RC, Teerlink JR, Vanhaecke J, Vinereanu D, Wong RC; PARADIGM-HF Investigators and Coordinators. Circulation. 2015 Jan 6;131(1):54-61. doi: 10.1161/CIRCULATIONAHA.114.013748. Epub 2014 Nov 17.

Prediction and personalised treatment of atrial fibrillation-stroke prevention: consolidated position paper of CVD professionals.
Helms TM, Duong G, Zippel-Schultz B, Tilz RR, Kuck KH, Karle CA. EPMA J. 2014 Sep 2;5(1):15. doi: 10.1186/1878-5085-5-15. eCollection 2014. Review.

Angiotensin-neprilysin inhibition versus enalapril in heart failure.
McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR; PARADIGM-HF Investigators and Committees. N Engl J Med. 2014 Sep 11;371(11):993-1004. doi: 10.1056/NEJMoa1409077. Epub 2014 Aug 30.

Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF).
McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau J, Shi VC, Solomon SD, Swedberg K, Zile MR; PARADIGM-HF Committees and Investigators. Eur J Heart Fail. 2013 Sep;15(9):1062-73. doi: 10.1093/eurjhf/hft052. Epub 2013 Apr 5.

Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A.
Kulzer M, Seyler C, Welke F, Scherer D, Xynogalos P, Scholz EP, Thomas D, Becker R, Karle CA, Katus HA, Zitron E. Biochem Biophys Res Commun. 2012 Jun 27. [Epub ahead of print]

TASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation.
Seyler C, Duthil-Straub E, Zitron E, Gierten J, Scholz EP, Fink RH, Karle CA, Becker R, Katus HA, Thomas D. Br J Pharmacol. 2012 Mar;165(5):1467-75. doi: 10.1111/j.1476-5381.2011.01626.x.

Central role of PKCα in isoenzyme-selective regulation of cardiac transient outward current Ito and Kv4.3 channels.
Scholz EP, Welke F, Joss N, Seyler C, Zhang W, Scherer D, Völkers M, Bloehs R, Thomas D, Katus HA, Karle CA, Zitron E. J Mol Cell Cardiol. 2011 Nov;51(5):722-9. Epub 2011 Jul 22.

Reconstitution of defective protein trafficking rescues Long-QT syndrome in zebrafish.
Meder B, Scholz EP, Hassel D, Wolff C, Just S, Berger IM, Patzel E, Karle C, Katus HA, Rottbauer W. Biochem Biophys Res Commun. 2011 May 6;408(2):218-24. Epub 2011 Mar 31.

Cardiovascular ion channels as a molecular target of flavonoids.
Scholz EP, Zitron E, Katus HA, Karle CA. Cardiovasc Ther. 2010 Aug;28(4):e46-52. Review.

Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine.
Obers S, Staudacher I, Ficker E, Dennis A, Koschny R, Erdal H, Bloehs R, Kisselbach J, Karle CA, Schweizer PA, Katus HA, Thomas D. Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):385-400. Epub 2010 Mar 13.

The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone.
Gierten J, Ficker E, Bloehs R, Schweizer PA, Zitron E, Scholz E, Karle C, Katus HA, Thomas D. Naunyn Schmiedebergs Arch Pharmacol. 2010 Mar;381(3):261-70. Epub 2009 Sep 24.

Biophysical characterization of KCNQ1 P320 mutations linked to long QT syndrome 1.
Thomas D, Khalil M, Alter M, Schweizer PA, Karle CA, Wimmer AB, Licka M, Katus HA, Koenen M, Ulmer HE, Zehelein J. J Mol Cell Cardiol. 2010 Jan;48(1):230-7. Epub 2009 Jun 21.

Biophysical properties of zebrafish ether-à-go-go related gene potassium channels.
Scholz EP, Niemer N, Hassel D, Zitron E, Bürgers HF, Bloehs R, Seyler C, Scherer D, Thomas D, Kathöfer S, Katus HA, Rottbauer WA, Karle CA. Biochem Biophys Res Commun. 2009 Apr 3;381(2):159-64. Epub 2009 Feb 14.

Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents.
Scherer D, Hassel D, Bloehs R, Zitron E, von Löwenstern K, Seyler C, Thomas D, Konrad F, Bürgers HF, Seemann G, Rottbauer W, Katus HA, Karle CA, Scholz EP. Br J Pharmacol. 2009 Jan;156(2):226-36. Epub 2009 Jan 16.

Dual regulation of renal Kir7.1 potassium channels by protein Kinase A and protein Kinase C.
Zhang W, Zitron E, Bloehs R, Müller-Krebs S, Scholz E, Zeier M, Katus H, Karle C, Schwenger V. Biochem Biophys Res Commun. 2008 Dec 19;377(3):981-6. Epub 2008 Oct 29.

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.
Gierten J, Ficker E, Bloehs R, Schlömer K, Kathöfer S, Scholz E, Zitron E, Kiesecker C, Bauer A, Becker R, Katus HA, Karle CA, Thomas D. Br J Pharmacol. 2008 Aug;154(8):1680-90. Epub 2008 Jun 2.

Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin.
Scherer D, von Löwenstern K, Zitron E, Scholz EP, Bloehs R, Kathöfer S, Thomas D, Bauer A, Katus HA, Karle CA, Kiesecker C. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):73-83. Epub 2008 May 6.

Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants.
Hassel D, Scholz EP, Trano N, Friedrich O, Just S, Meder B, Weiss DL, Zitron E, Marquart S, Vogel B, Karle CA, Seemann G, Fishman MC, Katus HA, Rottbauer W. Circulation. 2008 Feb 19;117(7):866-75. Epub 2008 Feb 4.

Doxazosin induces apoptosis of cells expressing hERG K+ channels.
Thomas D, Bloehs R, Koschny R, Ficker E, Sykora J, Kiehn J, Schlömer K, Gierten J, Kathöfer S, Zitron E, Scholz EP, Kiesecker C, Katus HA, Karle CA. Eur J Pharmacol. 2008 Jan 28;579(1-3):98-103. Epub 2007 Dec 4.

Kir2.x inward rectifier potassium channels are differentially regulated by adrenergic alpha1A receptors.
Zitron E, Günth M, Scherer D, Kiesecker C, Kulzer M, Bloehs R, Scholz EP, Thomas D, Weidenhammer C, Kathöfer S, Bauer A, Katus HA, Karle CA. J Mol Cell Cardiol. 2008 Jan;44(1):84-94. Epub 2007 Oct 18.

Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.
Scholz EP, Konrad FM, Weiss DL, Zitron E, Kiesecker C, Bloehs R, Kulzer M, Thomas D, Kathöfer S, Bauer A, Maurer MH, Seemann G, Katus HA, Karle CA. Naunyn Schmiedebergs Arch Pharmacol. 2007 Dec;376(4):275-84. Epub 2007 Oct 27.

Green tea flavonoid epigallocatechin-3-gallate (EGCG) inhibits cardiac hERG potassium channels.
Kelemen K, Kiesecker C, Zitron E, Bauer A, Scholz E, Bloehs R, Thomas D, Greten J, Remppis A, Schoels W, Katus HA, Karle CA. Biochem Biophys Res Commun. 2007 Dec 21;364(3):429-35. Epub 2007 Oct 9.

Activation of inwardly rectifying Kir2.x potassium channels by beta 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2.
Scherer D, Kiesecker C, Kulzer M, Günth M, Scholz EP, Kathöfer S, Thomas D, Maurer M, Kreuzer J, Bauer A, Katus HA, Karle CA, Zitron E. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jul;375(5):311-22. Epub 2007 May 30.

Aquaporin-1 channel function is positively regulated by protein kinase C.
Zhang W, Zitron E, Hömme M, Kihm L, Morath C, Scherer D, Hegge S, Thomas D, Schmitt CP, Zeier M, Katus H, Karle C, Schwenger V. J Biol Chem. 2007 Jul 20;282(29):20933-40. Epub 2007 May 23.

Atrial septal aneurysm mimicking ECG signs of enlarged right atrium.
Scholz EP, Zitron E, Katus HA, Karle CA, Mereles D. Europace. 2007 Jul;9(7):475-6. Epub 2007 May 15.

Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.
Scholz EP, Zitron E, Kiesecker C, Thomas D, Kathöfer S, Kreuzer J, Bauer A, Katus HA, Remppis A, Karle CA, Greten J. Nutr Metab Cardiovasc Dis. 2007 Nov;17(9):666-75. Epub 2006 Aug 22.

The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications.
Thomas D, Karle CA, Kiehn J. Curr Pharm Des. 2006;12(18):2271-83. Review.

Effect of pre-treatment with catecholamines on cold preservation and ischemia/reperfusion-injury in rats.
Gottmann U, Brinkkoetter PT, Bechtler M, Hoeger S, Karle C, Schaub M, Schnuelle P, Yard B, van der Woude FJ, Braun C. Kidney Int. 2006 Jul;70(2):321-8. Epub 2006 Jun 7.

Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels.
Kiesecker C, Alter M, Kathöfer S, Zitron E, Scholz EP, Thomas D, Kreuzer J, Katus HA, Bauer A, Karle CA. Naunyn Schmiedebergs Arch Pharmacol. 2006 Jun;373(3):212-20. Epub 2006 May 12.

In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform.
Scholz EP, Alter M, Zitron E, Kiesecker C, Kathöfer S, Thomas D, Kreye VA, Kreuzer J, Becker R, Katus HA, Greten J, Karle CA. Toxicol Lett. 2006 Aug 20;165(2):156-66. Epub 2006 Mar 27.

K+ channel activation with minoxidil stimulates nasal-epithelial ion transport and blunts exaggerated hypoxic pulmonary hypertension.
Peth S, Karle C, Dehnert C, Bärtsch P, Mairbäurl H. High Alt Med Biol. 2006 Spring;7(1):54-63.

[Molecular basis of primary electrical heart diseases].
Zitron E, Scholz EP, Kiesecker C, Pirot M, Kathöfer S, Thomas D, Kiehn J, Katus HA, Becker R, Karle CA. Herzschrittmacherther Elektrophysiol. 2005 Dec;16(4):229-38. Review. German.

Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1.
Kiesecker C, Zitron E, Scherer D, Lueck S, Bloehs R, Scholz EP, Pirot M, Kathöfer S, Thomas D, Kreye VA, Kiehn J, Borst MM, Katus HA, Schoels W, Karle CA. J Mol Med (Berl). 2006 Jan;84(1):46-56. Epub 2005 Oct 29.

The novel antiarrhythmic drug dronedarone: comparison with amiodarone.
Kathofer S, Thomas D, Karle CA. Cardiovasc Drug Rev. 2005 Fall;23(3):217-30. Review.

Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation.
Scholz EP, Zitron E, Kiesecker C, Lück S, Thomas D, Kathöfer S, Kreye VA, Katus HA, Kiehn J, Schoels W, Karle CA. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):516-25. Epub 2005 Jul 9.

Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome.
Thomas D, Wimmer AB, Karle CA, Licka M, Alter M, Khalil M, Ulmer HE, Kathöfer S, Kiehn J, Katus HA, Schoels W, Koenen M, Zehelein J. Cardiovasc Res. 2005 Aug 15;67(3):487-97.

QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids.
Zitron E, Scholz E, Owen RW, Lück S, Kiesecker C, Thomas D, Kathöfer S, Niroomand F, Kiehn J, Kreye VA, Katus HA, Schoels W, Karle CA. Circulation. 2005 Feb 22;111(7):835-8. Epub 2005 Feb 14.

Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action.
Kiesecker C, Zitron E, Lück S, Bloehs R, Scholz EP, Kathöfer S, Thomas D, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec;370(6):423-35. Epub 2004 Oct 30.

Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X).
Thomas D, Hammerling BC, Wimmer AB, Wu K, Ficker E, Kuryshev YA, Scherer D, Kiehn J, Katus HA, Schoels W, Karle CA. Cardiovasc Res. 2004 Dec 1;64(3):467-76.

Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome.
Zehelein J, Thomas D, Khalil M, Wimmer AB, Koenen M, Licka M, Wu K, Kiehn J, Brockmeier K, Kreye VA, Karle CA, Katus HA, Ulmer HE, Schoels W. Biochim Biophys Acta. 2004 Nov 5;1690(3):185-92.

Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors.
Thomas D, Wu K, Wimmer AB, Zitron E, Hammerling BC, Kathöfer S, Lueck S, Bloehs R, Kreye VA, Kiehn J, Katus HA, Schoels W, Karle CA. J Mol Med (Berl). 2004 Dec;82(12):826-37. Epub 2004 Sep 8.

Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone.
Zitron E, Kiesecker C, Scholz E, Lück S, Bloehs R, Kathöfer S, Thomas D, Kiehn J, Kreye VA, Katus HA, Schoels W, Karle CA. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):146-56. Epub 2004 Jul 29.

Human cardiac inwardly rectifying current IKir2.2 is upregulated by activation of protein kinase A.
Zitron E, Kiesecker C, Lück S, Kathöfer S, Thomas D, Kreye VA, Kiehn J, Katus HA, Schoels W, Karle CA. Cardiovasc Res. 2004 Aug 15;63(3):520-7.

Adrenergic regulation of the rapid component of the cardiac delayed rectifier potassium current, I(Kr), and the underlying hERG ion channel.
Thomas D, Kiehn J, Katus HA, Karle CA. Basic Res Cardiol. 2004 Jul;99(4):279-87. Epub 2004 Apr 8. Review.

Modulation of HERG potassium channel function by drug action.
Thomas D, Karle CA, Kiehn J. Ann Med. 2004;36 Suppl 1:41-6.

Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.
Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker EK, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathöfer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J. Br J Pharmacol. 2004 Jun;142(3):485-94. Epub 2004 May 17.

Radiation therapy-induced electrical reset of an implantable cardioverter defibrillator device located outside the irradiation field.
Thomas D, Becker R, Katus HA, Schoels W, Karle CA. J Electrocardiol. 2004 Jan;37(1):73-4.

Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin.
Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA. Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):462-72. Epub 2004 Apr 20.

Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells.
Karle C, Gehrig T, Wodopia R, Höschele S, Kreye VA, Katus HA, Bärtsch P, Mairbäurl H. Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1154-60. Epub 2004 Jan 16. Erratum in: Am J Physiol Lung Cell Mol Physiol. 2004 Oct;31(4):L890.

Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing.
Thomas D, Kiehn J, Katus HA, Karle CA. Cardiovasc Res. 2003 Nov 1;60(2):235-41. Review.

Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine.
Scholz EP, Zitron E, Kiesecker C, Lueck S, Kathöfer S, Thomas D, Weretka S, Peth S, Kreye VA, Schoels W, Katus HA, Kiehn J, Karle CA. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):404-14. Epub 2003 Oct 14.

Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels.
Thomas D, Kathofer S, Zhang W, Wu K, Wimmer AB, Zitron E, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J. Br J Pharmacol. 2003 Nov;140(5):996-1002. Epub 2003 Sep 29.

Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein.
Kathöfer S, Röckl K, Zhang W, Thomas D, Katus H, Kiehn J, Kreye V, Schoels W, Karle C. Naunyn Schmiedebergs Arch Pharmacol. 2003 Aug;368(2):119-26. Epub 2003 Jul 19.

Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein.
Thomas D, Zhang W, Wu K, Wimmer AB, Gut B, Wendt-Nordahl G, Kathöfer S, Kreye VA, Katus HA, Schoels W, Kiehn J, Karle CA. Cardiovasc Res. 2003 Jul 1;59(1):14-26.

Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen.
Thomas D, Gut B, Karsai S, Wimmer AB, Wu K, Wendt-Nordahl G, Zhang W, Kathöfer S, Schoels W, Katus HA, Kiehn J, Karle CA. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):41-8. Epub 2003 Jun 25.

The antipsychotic drug chlorpromazine inhibits HERG potassium channels.
Thomas D, Wu K, Kathöfer S, Katus HA, Schoels W, Kiehn J, Karle CA. Br J Pharmacol. 2003 Jun;139(3):567-74.

Ventricular oversensing: a study of 101 patients implanted with dual chamber defibrillators and two different lead systems.
Weretka S, Michaelsen J, Becker R, Karle CA, Voss F, Hilbel T, Osswald BR, Bahner ML, Senges JC, Kuebler W, Schoels W. Pacing Clin Electrophysiol. 2003 Jan;26(1 Pt 1):65-70.

Human cardiac inwardly-rectifying K+ channel Kir(2.1b) is inhibited by direct protein kinase C-dependent regulation in human isolated cardiomyocytes and in an expression system.
Karle CA, Zitron E, Zhang W, Wendt-Nordahl G, Kathöfer S, Thomas D, Gut B, Scholz E, Vahl CF, Katus HA, Kiehn J. Circulation. 2002 Sep 17;106(12):1493-9.

Bertosamil blocks HERG potassium channels in their open and inactivated states.
Zitron E, Karle CA, Wendt-Nordahl G, Kathöfer S, Zhang W, Thomas D, Weretka S, Kiehn J. Br J Pharmacol. 2002 Sep;137(2):221-8.

The antiarrhythmic drug BRL-32872.
Karle CA, Thomas D, Kiehn J. Cardiovasc Drug Rev. 2002 Summer;20(2):111-20. Review.

Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line.
Wei Z, Thomas D, Karle CA, Kathöfer S, Schenkel J, Kreye VA, Ficker E, Wible BA, Kiehn J. Chin Med J (Engl). 2002 May;115(5):668-76.

Vascular effects of class-III antiarrhythmic drugs: chromanol 293B, but not dofetilide blocks the smooth muscle delayed rectifier K+ channel.
Karle CA, Bauer A, Weretka S, Zitron E, Abushi A, Kreye VA, Schoels W. Basic Res Cardiol. 2002 Jan;97(1):17-25.

Effects of the I(Kr)-blocking agent dofetilide and of the I(Ks)-blocking agent chromanol 293b on regional disparity of left ventricular repolarization in the intact canine heart.
Bauer A, Becker R, Karle C, Schreiner KD, Senges JC, Voss F, Kraft P, Kuebler W, Schoels W. J Cardiovasc Pharmacol. 2002 Mar;39(3):460-7.

Rapid component I(Kr) of the guinea-pig cardiac delayed rectifier K(+) current is inhibited by beta(1)-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways.
Karle CA, Zitron E, Zhang W, Kathöfer S, Schoels W, Kiehn J. Cardiovasc Res. 2002 Feb 1;53(2):355-62.

An ion channel 'addicted' to ether, alcohol and cocaine: the HERG potassium channel.
Karle CA, Kiehn J. Cardiovasc Res. 2002 Jan;53(1):6-8. Review. No abstract available.

Far-field R wave oversensing in a dual chamber arrhythmia management device: predisposing factors and practical implications.
Weretka S, Becker R, Hilbel T, Karle C, Osswald BR, Kuebler W, Schoels W. Pacing Clin Electrophysiol. 2001 Aug;24(8 Pt 1):1240-6.

Antiarrhythmic drug carvedilol inhibits HERG potassium channels.
Karle CA, Kreye VA, Thomas D, Röckl K, Kathöfer S, Zhang W, Kiehn J. Cardiovasc Res. 2001 Feb 1;49(2):361-70.

Functional coupling of human beta 3-adrenoreceptors to the KvLQT1/MinK potassium channel.
Kathöfer S, Zhang W, Karle C, Thomas D, Schoels W, Kiehn J. J Biol Chem. 2000 Sep 1;275(35):26743-7.

Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A.
Thomas D, Zhang W, Karle CA, Kathöfer S, Schöls W, Kübler W, Kiehn J. J Biol Chem. 1999 Sep 24;274(39):27457-62.

Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels.
Kiehn J, Thomas D, Karle CA, Schöls W, Kübler W. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):212-9.

A K+ single channel and whole-cell clamp study on the effects of levocromakalim in guinea pig portal vein cells.
Karle CA, Yao X, Kreye VA. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):374-81.

HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways.
Kiehn J, Karle C, Thomas D, Yao X, Brachmann J, Kübler W. J Biol Chem. 1998 Sep 25;273(39):25285-91.